Results for 'Julia D. Sigwart'

998 found
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  1.  6
    Why is there no service to support taxonomy?Julia D. Sigwart, Chong Chen, Ekin Tilic, Miguel Vences & Torben Riehl - 2023 - Bioessays 45 (9):2300070.
    Increasing complexity and specialisation of modern sciences has led to increasingly collaborative publications, as well as the involvement of commercial services. Modern integrative taxonomy likewise depends on many lines of evidence and is increasingly complex, but the trend of collaboration lags and various attempts at ‘turbo taxonomy’ have been unsatisfactory. We are developing a taxonomic service in the Senckenberg Ocean Species Alliance to provide fundamental data for new species descriptions. This will also function as a hub to connect a global (...)
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  2.  54
    The Voices Missing from the Autonomy Discourse.Julia D. Gibson - 2019 - International Journal of Feminist Approaches to Bioethics 12 (1):77-98.
    Jonathan Beever and Nicolae Morar’s article “The Porosity of Autonomy: Social and Biological Constitution of the Patient in Biomedicine” and its accompanying commentaries in the American Journal of Bioethics—though insightful, innovative, and provocative—overlook key interlocutors necessary for any discussion of whether the mid-twentieth-century biomedical principle of autonomy should be revised or revoked. The conversation sparked by “The Porosity of Autonomy” will remain both incomplete and politically untenable so long as there is no meaningful engagement with persons/communities who appeal to the (...)
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  3.  11
    Cynthia's Birthday Acrostic (3.10.1–5): Propertius on Elegiac Time and Eternity.Julia D. Hejduk - 2023 - Classical Quarterly 73 (2):714-720.
    This article argues that an intentional acrostic spanning the first five lines of Propertius’ elegy for Cynthia's birthday (3.10), MANE[T], contributes significantly to the poignancy and purpose of the poem. MANE can be read as māne, ‘in the morning’, or manē, ‘stay!’, both of which emphasize the fleeting nature of dawn—and of Cynthia's youthful beauty. MANET can suggest both ‘[art] remains’ and ‘[death] awaits’. All four of these meanings work together to capture the tension between human transience and artistic immortality. (...)
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  4. Should we adopt a market strategy to organ donation?Julia D. Mahoney - 2001 - Advances in Bioethics 7:65-88.
     
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  5.  18
    Facing the Minotaur:" Inception"(2010) and" Aeneid" 6.Julia D. Hejduk - 2011 - Arion 19 (2):93-104.
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  6.  9
    Introduction: Reading Civil War.Julia D. Hejduk - 2017 - Classical World: A Quarterly Journal on Antiquity 111 (1):1-5.
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  7.  7
    The Liberal Arts and Virgil’s Aeneid: What Can the Greatest Text Teach Us?Julia D. Hejduk - 2022 - Principia: A Journal of Classical Education 1 (1):15-26.
    As the classic of classics and the bridge between pagan antiquity and the Christian era, Virgil’s Aeneid stands at the center of the humanities’ Great Conversation. Yet this poem of Empire, with its flawed hero and its ambivalence toward divine and temporal power, raises more questions than it answers about the nature of human history. The epic’s true moral complexity, mirroring the insoluble conundrum that is human life, makes it especially relevant in an era whose political polarization resembles civil war. (...)
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  8.  34
    Just Fanciers: Transformative Justice by Way of Fancy Rat Breeding as a Loving Form of Life.Julia D. Gibson - 2019 - Journal of Agricultural and Environmental Ethics 32 (1):105-126.
    A growing trend within feminist animal studies is to eschew the abolitionism/welfarism binary in favor of attending carefully to the politics of existing interspecies relationships in context. This literature maintains that domestication produces special interspecies relationships which generate ongoing responsibilities for human companions and communities. With the goal of clarifying how tending to these ongoing responsibilities to domesticated animals can qualify as enduring forms of interspecies justice, this paper unpacks the politics of these special relationships and obligations in context, specifically, (...)
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  9.  59
    Climate Justice for the Dead and the Dying.Julia D. Gibson - 2021 - Environmental Philosophy 18 (1):5-39.
    Environmentalism has long placed heavy emphasis on strategies that seek to ensure the environment of today and the future roughly mirror the past. Yet while past-oriented approaches have come under increased scrutiny, environmental ethics in the time of climate change is still largely conceptualized as that which could pull humanity back from the brink of disaster or, at least, prevent the worst of it. As a result, practical and conceptual tools for grappling with what is owed to the dead and (...)
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  10.  11
    Holographic Ethics for Intergenerational Justice.Julia D. Gibson - 2022 - Environmental Philosophy 19 (2):141-162.
    Building off Manulani Aluli-Meyer’s theory of holographic epistemology, this article explores how our understanding of intergenerational justice shifts when informed by relational interspecies ethics and nonlinear temporalities. Both intergenerational and interspecies ethics are greatly enriched if the dead, the living, and those yet-to-be are not (only) distinct generations of beings along a linear sequence but coexistent facets of every being. The second focal point of this article concerns what holographic epistemology reveals about Dipesh Chakrabarty’s notion of the planetary. Ultimately, the (...)
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  11.  16
    Holographic Ethics for Intergenerational Justice.Julia D. Gibson - 2022 - Environmental Philosophy 19 (2):141-162.
    Building off Manulani Aluli-Meyer’s theory of holographic epistemology, this article explores how our understanding of intergenerational justice shifts when informed by relational interspecies ethics and nonlinear temporalities. Both intergenerational and interspecies ethics are greatly enriched if the dead, the living, and those yet-to-be are not distinct generations of beings along a linear sequence but coexistent facets of every being. The second focal point of this article concerns what holographic epistemology reveals about Dipesh Chakrabarty’s notion of the planetary. Ultimately, the article (...)
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  12.  6
    The Indispensability of Holistic Species Experts for Ethical Animal Research.Julia D. Gibson - 2021 - Journal of Agricultural and Environmental Ethics 34 (6):1-18.
    Committee composition is a recurrent theme within the literature on Institutional Animal Care and Use Committees (IACUCs). The ability of IACUCs to ensure the ethical treatment of nonhuman research subjects depends upon who makes up these committees. Non-scientists and those not affiliated with the research institution have been deemed indispensable for the democratic, objective review of protocols and, thus, for ethical treatment. IACUCs’ critics and partners alike have persistently offered suggestions for how to further optimize committee composition towards these ends. (...)
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  13.  23
    Fountains of Love: The Maternal Body as Rhetorical Symbol of Authority in Early Modern England.Julia D. Combs - 2018 - Journal of Early Modern Studies 7 (2):55-71.
    For Erasmus, the two fountains streaming milky juice—a new mother’s breasts—represent powerful symbols of love and authority. Erasmus describes the mother’s breasts as fountains oozing love to the sucking child. Elizabeth Clinton extends the image of Mother to represent God, reminding the nursing mother that when she looks on her sucking child, she should remember that she is God’s new born babe, sucking His instruction and His word, even as the babe sucks her breast. Dorothy Leigh extends the image of (...)
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  14.  47
    Pupils' perceptions of foreign language learning at 12+: Some gender differences.Robert C. Powell & Julia D. Batters - 1985 - Educational Studies 11 (1):11-23.
  15.  7
    NDN Collective Climate Justice Campaign, editor. Required Reading: Climate Justice, Adaptation and Investing in Indigenous Power. [REVIEW]Julia D. Gibson - 2022 - Environmental Ethics 44 (4):371-374.
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  16.  36
    Culture of honour theory and social anxiety: Cross-regional and sex differences in relationships among honour-concerns, social anxiety and reactive aggression.Ashley N. Howell, Julia D. Buckner & Justin W. Weeks - 2015 - Cognition and Emotion 29 (3):568-577.
  17. Differential effects of socioeconomic status on working and procedural memory systems.Julia A. Leonard, Allyson P. Mackey, Amy S. Finn & John D. E. Gabrieli - 2015 - Frontiers in Human Neuroscience 9.
  18.  16
    Brain Network Oscillations During Gait in Parkinson’s Disease.Doris D. Wang & Julia T. Choi - 2020 - Frontiers in Human Neuroscience 14.
  19.  23
    Inductive reasoning in folkbiological thought.John D. Coley, Douglas L. Medin, Julia Beth Proffitt, Elizabeth Lynch & Scott Atran - 1999 - In D. Medin & S. Atran (eds.), Folkbiology. MIT Press. pp. 211-12.
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  20.  22
    Development pathways at the agriculture–urban interface: the case of Central Arizona.Julia C. Bausch, Hallie Eakin, Skaidra Smith-Heisters, Abigail M. York, Dave D. White, Cathy Rubiños & Rimjhim M. Aggarwal - 2015 - Agriculture and Human Values 32 (4):743-759.
    Particular visions of urban development are often codified in multi-year resource management policies. These policies, and the negotiations leading to them, are based in specific problem frames and narratives with long legacies. As conditions change and knowledge improves, there is often a need to revisit how problems, opportunities, and development pathways were defined historically, and to consider the viability of alternative pathways for development. In this article, we examine the case of agriculture near Metropolitan Phoenix, in the Central Arizona region, (...)
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  21.  20
    Erratum to: Limit computable integer parts.Paola D’Aquino, Julia Knight & Karen Lange - 2015 - Archive for Mathematical Logic 54 (3-4):487-489.
  22.  71
    Limit computable integer parts.Paola D’Aquino, Julia Knight & Karen Lange - 2011 - Archive for Mathematical Logic 50 (7-8):681-695.
    Let R be a real closed field. An integer part I for R is a discretely ordered subring such that for every \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r \in R}$$\end{document}, there exists an \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${i \in I}$$\end{document} so that i ≤ r < i + 1. Mourgues and Ressayre (J Symb Logic 58:641–647, 1993) showed that every real closed field has an integer part. The procedure of Mourgues and (...)
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  23.  46
    Manuscript Referees for The Journal of Ethics Volume 9: September 2004–June 2005.Justin D’Arms, Julia Driver, Anthony Ellis, Francisco Gonzales, George W. Harris, Aleksandar Jokic, Leonard Kahn, Phillip Montague, G. Di Muzio & Gerald Press - 2005 - The Journal of Ethics 9 (3):581.
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  24.  20
    Unique Encounters of the Medical KindEncounters between Patients and Doctors: An Anthology. [REVIEW]Julia E. Connelly & John D. Stoeckle - 1989 - Hastings Center Report 19 (1):40.
    Book reviewed in this article: Encounters Between Patients and Doctors: An Anthology. By John D. Stoeckle.
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  25. Stoici Antichi, a cura di Margherita Isnardi Parente, Torino 1989 (Classici UTET, 2 vols. 1309 páginas). M. Isnardi Parente, Introduzione a lo Stoicismo ellenistico, Roma-Bari 1993 (Laterza, Coll.“I filosofi” 196 páginas). [REVIEW]Victoria E. Julia & Marcelo D. Boeri - 1994 - Méthexis 7 (1):160-163.
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  26.  51
    Balancing Benefits and Risks of Immortal Data.Oscar A. Zarate, Julia Green Brody, Phil Brown, Monica D. Ramirez-Andreotta, Laura Perovich & Jacob Matz - 2015 - Hastings Center Report 46 (1):36-45.
    An individual's health, genetic, or environmental-exposure data, placed in an online repository, creates a valuable shared resource that can accelerate biomedical research and even open opportunities for crowd-sourcing discoveries by members of the public. But these data become “immortalized” in ways that may create lasting risk as well as benefit. Once shared on the Internet, the data are difficult or impossible to redact, and identities may be revealed by a process called data linkage, in which online data sets are matched (...)
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  27.  58
    Plato's Republic: Critical Essays.Richard Kraut, Julia Annas, John M. Cooper, Jonathan Lear, Iris Murdoch, C. D. C. Reeve, David Sachs, Arlene W. Saxonhouse, C. C. W. Taylor, James O. Urmson, Gregory Vlastos & Bernard Williams - 1997 - Rowman & Littlefield Publishers.
    Bringing between two covers the most influential and accessible articles on Plato's Republic, this collection illuminates what is widely held to be the most important work of Western philosophy and political theory. It will be valuable not only to philosophers, but to political theorists, historians, classicists, literary scholars, and interested general readers.
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  28. College Binge Drinking Associated with Decreased Frontal Activation to Negative Emotional Distractors during Inhibitory Control.Julia E. Cohen-Gilbert, Lisa D. Nickerson, Jennifer T. Sneider, Emily N. Oot, Anna M. Seraikas, Michael L. Rohan & Marisa M. Silveri - 2017 - Frontiers in Psychology 8.
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  29. Katrina and the privilege of despair: Welch's model of connection in teaching for social justice.Alicia D. Brown, Julia G. Brooks & Michael G. Gunzenhauser - 2007 - Philosophical Studies in Education 48:76 - 86.
     
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  30.  15
    ʿAbbasid Belles-LettresAbbasid Belles-Lettres.Stefan Leder, Julia Ashtiany, T. M. Johnstone, J. D. Latham, R. B. Serjeant, G. Rex Smith, ʿAbbasid Belles & Abbasid Belles - 1991 - Journal of the American Oriental Society 111 (4):785.
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  31.  11
    Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task.Andrea Katzorke, Julia B. M. Zeller, Laura D. Müller, Martin Lauer, Thomas Polak, Andreas Reif, Jürgen Deckert & Martin J. Herrmann - 2017 - Frontiers in Human Neuroscience 11.
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  32.  67
    Rediscovering Waddington in the post‐genomic age.Heather A. Jamniczky, Julia C. Boughner, Campbell Rolian, Paula N. Gonzalez, Christopher D. Powell, Eric J. Schmidt, Trish E. Parsons, Fred L. Bookstein & Benedikt Hallgrímsson - 2010 - Bioessays 32 (7):553-558.
  33.  18
    Women and Gender in the State of SympathyStates of Sympathy: Seduction and Democracy in the American NovelThe Plight of Feeling: Sympathy and Dissent in the Early American NovelFathering the Nation: American Genealogies of Slavery and FreedomThat Pale Mother Rising: Sentimental Discourses and the Imitation of Motherhood in Nineteenth-Century AmericaConceived by Liberty: Maternal Figures and Nineteenth-Century American LiteratureHome Fronts: Domesticity and Its Critics.Dana D. Nelson, Elizabeth Barnes, Julia A. Stern, Russ Castronovo, Eva Cherniavsky, Stephanie Smith & Lora Romero - 2002 - Feminist Studies 28 (1):175.
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  34. Cognitive and Physiological Measures in Well-Being Science: Limitations and Lessons.Benjamin D. Yetton, Julia Revord, Seth Margolis, Sonja Lyubomirsky & Aaron R. Seitz - 2019 - Frontiers in Psychology 10.
    Social and personality psychology have been criticized for overreliance on potentially biased self-report variables. In well-being science, researchers have called for more “objective” physiological and cognitive measures to evaluate the efficacy of well-being-increasing interventions. This may now be possible with the recent rise of cost-effective, commercially-available wireless physiological recording devices and smartphone-based cognitive testing. We sought to determine whether cognitive and physiological measures, coupled with machine learning methods, could quantify the effects of positive interventions. The current 2-part study used a (...)
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  35.  9
    Can an Online Reading Camp Teach 5-Year-Old Children to Read?Yael Weiss, Jason D. Yeatman, Suzanne Ender, Liesbeth Gijbels, Hailley Loop, Julia C. Mizrahi, Bo Y. Woo & Patricia K. Kuhl - 2022 - Frontiers in Human Neuroscience 16.
    Literacy is an essential skill. Learning to read is a requirement for becoming a self-providing human being. However, while spoken language is acquired naturally with exposure to language without explicit instruction, reading and writing need to be taught explicitly. Decades of research have shown that well-structured teaching of phonological awareness, letter knowledge, and letter-to-sound mapping is crucial in building solid foundations for the acquisition of reading. During the COVID-19 pandemic, children worldwide did not have access to consistent and structured teaching (...)
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  36.  10
    Macaque Gaze Responses to the Primatar: A Virtual Macaque Head for Social Cognition Research.Vanessa A. D. Wilson, Carolin Kade, Sebastian Moeller, Stefan Treue, Igor Kagan & Julia Fischer - 2020 - Frontiers in Psychology 11.
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  37.  72
    Symmetry Breaking Analysis of Prism Adaptation’s Latent Aftereffect.Till D. Frank, Julia J. C. Blau & Michael T. Turvey - 2012 - Cognitive Science 36 (4):674-697.
    The effect of prism adaptation on movement is typically reduced when the movement at test (prisms off) differs on some dimension from the movement at training (prisms on). Some adaptation is latent, however, and only revealed through further testing in which the movement at training is fully reinstated. Applying a nonlinear attractor dynamic model (Frank, Blau, & Turvey, 2009) to available data (Blau, Stephen, Carello, & Turvey, 2009), we provide evidence for a causal link between the latent (or secondary) aftereffect (...)
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  38. Inattentional blindness versus inattentional amnesia for fixated but ignored words.Geraint Rees, C. Russell, Christopher D. Frith & Julia Driver - 1999 - Science 286 (5449):2504-7.
  39.  17
    Partner Gender Differences in Prestige of Clients Served at the Largest U.S. Audit Firms.Elizabeth D. Almer, M. Kathleen Harris, Julia L. Higgs & Joseph R. Rakestraw - 2020 - Journal of Business Ethics 173 (2):401-421.
    Despite tremendous investment to promote gender equity, U.S. public accounting firms continue to be gendered organizations. Our archival study examines gender equity within the partnership of these large firms for a one-year period. We find female partners are clustered in lower prestige client types including investment funds, benefit plans, and single audits, rather than higher prestige public company clients. Second, we consider whether there is gender bias in prestige of client served by female partners who lead public company audits. In (...)
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  40.  59
    Unconscious activation of visual cortex in the damaged right hemisphere of a parietal patient with extinction.Geraint Rees, E. Wojciulik, Karen Clarke, Masud Husain, Christopher D. Frith & Julia Driver - 2000 - Brain 123 (8):1624-1633.
  41.  76
    Plato's 'Republic': A Critical Guide.Mark L. Mcpherran, G. R. F. Ferrari, Rachel Barney, Julia Annas, Rachana Kamtekar & Nicholas D. Smith (eds.) - 2013 - New York: Cambridge University Press.
    Plato's Republic has proven to be of astounding influence and importance. Justly celebrated as Plato's central text, it brings together all of his prior works, unifying them into a comprehensive vision that is at once theological, philosophical, political and moral. The essays in this volume provide a picture of the most interesting aspects of the Republic, and address questions that continue to puzzle and provoke, such as: Does Plato succeed in his argument that the life of justice is the most (...)
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  42.  28
    Quantitative Perspectives on Fifty Years of the Journal of the History of Biology.B. R. Erick Peirson, Erin Bottino, Julia L. Damerow & Manfred D. Laubichler - 2017 - Journal of the History of Biology 50 (4):695-751.
    Journal of the History of Biology provides a fifty-year long record for examining the evolution of the history of biology as a scholarly discipline. In this paper, we present a new dataset and preliminary quantitative analysis of the thematic content of JHB from the perspectives of geography, organisms, and thematic fields. The geographic diversity of authors whose work appears in JHB has increased steadily since 1968, but the geographic coverage of the content of JHB articles remains strongly lopsided toward the (...)
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  43.  23
    An Ethical Marketing Approach to Wicked Problems: Macromarketing for the Common Good.Thomas G. Pittz, Susan D. Steiner & Julia R. Pennington - 2020 - Journal of Business Ethics 164 (2):301-310.
    Macromarketing attempts to address issues that engage marketing and society and previous ethical scholarship has focused on distributive justice and on exchanges that occur in conventional markets. As our research highlights, however, the distributive justice approach alone is insufficient for managing the complexities, ethical paradoxes, and out-of-market conditions associated with wicked, cross-national social concerns. In this article, we integrate macromarketing with the theory of the common good in order to provide a foundation for framing societal change that can encompass nonmarket (...)
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  44. II_– _Julia Tanney: Normativity and Thought.Julia Tanney - 1999 - Aristotelian Society Supplementary Volume 73 (1):45-61.
    [David Papineau] This paper disputes the common assumption that the normativity of conceptual judgement poses a problem for naturalism. My overall strategy is to argue that norms of judgement derive from moral or personal values, particularly when such values are attached to the end of truth. While there are philosophical problems associated with both moral and personal values, they are not special to the realm of judgement, nor peculiar to naturalist philosophies. This approach to the normativity of judgement is made (...)
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  45.  7
    Understanding the challenges faced by Michigan’s family farmers: race/ethnicity and the impacts of a pandemic.Dorceta E. Taylor, Lina M. Farias, Lia M. Kahan, Julia Talamo, Alison Surdoval, Ember D. McCoy & Socorro M. Daupan - 2022 - Agriculture and Human Values 39 (3):1077-1096.
    Michigan is a critical agricultural state, and small family farms are a crucial component of the state’s food sector. This paper examines how the race/ethnicity of the family farm owners/operators is related to farm characteristics, financing, and impacts of the pandemic. It compares 75 farms owned/operated solely by Whites and 15 with People of Color owners/operators. The essay examines how farmers finance their farm operations and the challenges they face doing so. The article also explores how the Coronavirus-19 pandemic affected (...)
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  46.  12
    L’humain, la faune sauvage et la chasse : perspectives d’un système intégral de surveillance de la santé.Julia Brunn & Pierre-Henri Bréchat - 2024 - Médecine et Droit 2024 (185):37-46.
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  47.  12
    Editorial: Coronavirus Disease (COVID-19): Psychological and Behavioral Consequences of Confinement on Physical Activity, Sedentarism, and Rehabilitation.Luis Mochizuki, Michael Brach, Pedro L. Almeida, Ricardo De La Vega, Mauricio Garzon, Julia Maria D'Andrea Greve & Margarita Limon - 2022 - Frontiers in Psychology 13.
  48.  50
    The diversity of experimental organisms in biomedical research may be influenced by biomedical funding.B. R. Erick Peirson, Heather Kropp, Julia Damerow & Manfred D. Laubichler - 2017 - Bioessays 39 (5):1600258.
    Contrary to concerns of some critics, we present evidence that biomedical research is not dominated by a small handful of model organisms. An exhaustive analysis of research literature suggests that the diversity of experimental organisms in biomedical research has increased substantially since 1975. There has been a longstanding worry that organism‐centric funding policies can lead to biases in experimental organism choice, and thus negatively impact the direction of research and the interpretation of results. Critics have argued that a focus on (...)
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  49.  45
    When bins blur: Patient perspectives on categories of results from clinical whole genome sequencing.Leila Jamal, Jill O. Robinson, Kurt D. Christensen, Jennifer Blumenthal-Barby, Melody J. Slashinski, Denise Lautenbach Perry, Jason L. Vassy, Julia Wycliff, Robert C. Green & Amy L. McGuire - 2017 - AJOB Empirical Bioethics 8 (2):82-88.
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  50. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.David C. Whitcomb, Jessica LaRusch, Alyssa M. Krasinskas, Lambertus Klei, Jill P. Smith, Randall E. Brand, John P. Neoptolemos, Markus M. Lerch, Matt Tector, Bimaljit S. Sandhu, Nalini M. Guda, Lidiya Orlichenko, Samer Alkaade, Stephen T. Amann, Michelle A. Anderson, John Baillie, Peter A. Banks, Darwin Conwell, Gregory A. Coté, Peter B. Cotton, James DiSario, Lindsay A. Farrer, Chris E. Forsmark, Marianne Johnstone, Timothy B. Gardner, Andres Gelrud, William Greenhalf, Jonathan L. Haines, Douglas J. Hartman, Robert A. Hawes, Christopher Lawrence, Michele Lewis, Julia Mayerle, Richard Mayeux, Nadine M. Melhem, Mary E. Money, Thiruvengadam Muniraj, Georgios I. Papachristou, Margaret A. Pericak-Vance, Joseph Romagnuolo, Gerard D. Schellenberg, Stuart Sherman, Peter Simon, Vijay P. Singh, Adam Slivka, Donna Stolz, Robert Sutton, Frank Ulrich Weiss, C. Mel Wilcox, Narcis Octavian Zarnescu, Stephen R. Wisniewski, Michael R. O'Connell, Michelle L. Kienholz, Kathryn Roeder & M. Micha Barmada - unknown
    Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...)
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